Final cohort2,034
KRAS-mutated92.9%
Variant groups4
Overall log-rankp < .0001
How do overall-survival distributions differ among major KRAS groups in this PDAC cohort?
The analysis used the MSK Pancreatic Cancer Study 2024 from cBioPortal and formed a final comparison cohort of 865 G12D, 684 G12V, 340 G12R, and 145 KRAS wild-type patients.
- Study
pdac_msk_2024
- Endpoint
- Overall survival in months
- Methods
- Kaplan–Meier, log-rank, pairwise Cox models
- Comparison
- G12D, G12V, G12R, and wild type
Study discovery, clinical harmonization, KRAS grouping, and survival modeling
Retrieve study dataQueried cBioPortal clinical and mutation records for the MSK 2024 PDAC study.
Build groupsMapped patients to G12D, G12V, G12R, or KRAS wild type for the final comparison.
Estimate survivalGenerated Kaplan–Meier curves and an overall log-rank comparison.
Compare pairsEstimated Cox hazard ratios for each major variant group against wild type.
Median survival was shortest in G12D, but pairwise evidence differed by group
Median OS
Wild type 24.2 months, G12R 20.4, G12V 18.0, and G12D 15.4.
G12D vs WT
HR 1.56, 95% CI 1.246–1.954, p = .0001.
G12V vs WT
HR 1.379, 95% CI 1.095–1.736, p = .0061.
G12R vs WT
HR 1.283, 95% CI 0.995–1.655, p = .0546; not conventionally significant.
Inconsistent denominators and observational design require caution
- The PDF reports 2,336 study patients, 2,207 KRAS-mutated patients in one output, 2,270 complete survival records, and a 2,034-patient final four-group cohort.
- The Kaplan–Meier figure title reports N = 2,334 even though its displayed groups total 2,034.
- The analysis is unadjusted observational evidence and does not establish a causal or independently prognostic effect.
- Potential clinical confounders, treatment differences, stage, and selection effects were not modeled in the reported pairwise comparisons.
Confidence boundary
The within-report curves and comparisons are inspectable, but the denominator mismatch should be reconciled before publication-quality clinical inference.
Reproducibility artifacts recorded in the session
clinical_data_msk2024.csvClinical recordssurvival_data_msk2024.csvComplete survival fieldssurvival_analysis_dataset.csvModeled cohortkras_variant_summary.jsonVariant countsfinal_survival_summary.csvGroup survival summariespairwise_survival_results.csvHazard-ratio comparisonsOriginal session report10-page PDF with cohort construction, survival results, figures, and recorded runtime of 41.1 seconds.
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